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Potential bias in ophthalmic pharmaceutical clinical trials
Review
(2933) Views (704) Full article downloads
Authors: Paul Varner
Published Date June 2008
Volume 2008:2(2) Pages 401 - 411
DOI: http://dx.doi.org/10.2147/OPTH.S2561
Paul Varner
John J Pershing Veterans’ Administration Medical Center, Poplar Bluff, Missouri, USA
Abstract: To make clinicians aware of potential sources of error in ophthalmic pharmaceutical clinical trials that can lead to erroneous interpretation of results, a critical review of the study design of various pharmaceutical ophthalmic clinical trials was completed. Discrepancies as a result of study shortcomings may explain observed differences between reported ophthalmic trial data and observed clinical results.
Keywords: evidence-based medicine, validity, bias, gold standard
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