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Review

Potential bias in ophthalmic pharmaceutical clinical trials

       

Authors Varner P

Published 6 June 2008 Volume 2008:2(2) Pages 401—411

DOI https://doi.org/10.2147/OPTH.S2561

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Paul Varner

John J Pershing Veterans’ Administration Medical Center, Poplar Bluff, Missouri, USA

Abstract: To make clinicians aware of potential sources of error in ophthalmic pharmaceutical clinical trials that can lead to erroneous interpretation of results, a critical review of the study design of various pharmaceutical ophthalmic clinical trials was completed. Discrepancies as a result of study shortcomings may explain observed differences between reported ophthalmic trial data and observed clinical results.

Keywords: evidence-based medicine, validity, bias, gold standard

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