Menu
Back to Journals » International Journal of Nephrology and Renovascular Disease » Volume 3
Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment
Authors Halvorson CR, Bremmer M, Jacobs SC
Published 24 June 2010 Volume 2010:3 Pages 69—83
DOI https://doi.org/10.2147/IJNRD.S6939
Review by Single anonymous peer review
Peer reviewer comments 4
Christian R Halvorson1, Matthew S Bremmer1, Stephen C Jacobs1
1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Abstract: Both autosomal dominant and recessive polycystic kidney disease are conditions with severe associated morbidity and mortality. Recent advances in the understanding of the genetic and molecular pathogenesis of both ADPKD and ARPKD have resulted in new, targeted therapies designed to disrupt cell signaling pathways responsible for the abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristic of the disease. Herein we review the current understanding of the pathophysiology of these conditions, as well as the current treatments derived from our understanding of the mechanisms of these diseases.
Keywords: Polycystic kidney disease, autosomal dominant, recessive, end stage renal disease
© 2010 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.