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Phosphorylation at endothelial cell–cell junctions: Implications for VE-cadherin function

Review

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Authors: Ilse Timmerman, Peter L Hordijk, Jaap D van Buul

Published Date May 2010 Volume 2010:2 Pages 23 - 31
DOI: http://dx.doi.org/10.2147/CHC.S9590

Ilse Timmerman, Peter L Hordijk, Jaap D van Buul

Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands

Abstract: Endothelial cell–cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell–cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.

Keywords: endothelium, VE-cadherin, junctions, barrier, phosphorylation








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