skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Periorbital edema secondary to imatinib mesylate

Case report

(3205) Views  (766) Full article downloads

Authors: Collin M McClelland, George J Harocopos, Philip L Custer

Published Date May 2010 Volume 2010:4 Pages 427 - 431
DOI: http://dx.doi.org/10.2147/OPTH.S8521

Collin M McClelland, George J Harocopos, Philip L Custer

School of Medicine, Washington University, St. Louis, MO, USA

Abstract: Imatinib mesylate (Gleevec®) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib is well documented in the oncology literature, there is limited reference to this common reaction in the ophthalmology literature. We report two patients with upper eyelid edema associated with imatinib therapy who required surgical intervention to ameliorate significant visual field obstruction. We highlight the details of each case including the histopathologic findings of excised redundant skin followed by a thorough review of the literature on imatinib related periorbital edema.

Keywords: imatinib mesylate, gleevec, edema, periorbital edema, tyrosine kinase inhibitor








Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
The effect of pterygium surgery on contrast sensitivity and corneal topographic changes
Corneal abrasion
Patients’ knowledge and perspectives on wet age-related macular degeneration and its treatment
Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
A case of iridoschisis associated with lens displacement into the vitreous cavity
Perception of risk and benefit in patient-centered communication and care
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy