Patterns and predictors of antihypertensive medication used 1 year after ischemic stroke or TIA in urban China

Jie Xu,^* Yi Ju,^* Chunjuan Wang, Yilong Wang, Liping Liu, Xingquan Zhao, Chunxue Wang, Anxin Wang, Yongjun Wang

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

^*These authors contributed equally to this work

Background: Antihypertensive treatment is recommended for secondary prevention in patients with ischemic stroke or transient ischemic attack. Prescription of and persistence with antihypertensives for secondary prevention is high in developed countries; whether this is true in China is unclear. The aim of this study was to describe the patterns of antihypertensive medication use, and factors associated with its use, 1 year after stroke in China.
Methods: A total of 7880 hypertensive patients diagnosed with ischemic stroke or transient ischemic attack in the China National Stroke Registry were analyzed. Multivariate logistic regression was used to identify factors associated with antihypertensive medication use at discharge and 12 months.
Results: Antihypertensive medication was used by 4458 (56.6%) participants at discharge and 2927 (37.1%) at 12 months. Calcium channel blockers were the most common among five classes of antihypertensive medication prescribed at discharge, and participants prescribed this class had the highest 1-year persistence. In-hospital health education was the strongest predictor of antihypertensive medication use at discharge; age and stroke severity were the strongest negative predictors of use at 12 months.
Conclusion: Use of antihypertensive medication 1 year after stroke is extremely low in China. Intervention is needed to improve adherence to antihypertensive medication, especially for the elderly and severe stroke patients.

Keywords: antihypertensive agents, secondary stroke prevention, stroke