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Clinical Interventions in Aging
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Pathogenesis of Alzheimer′s disease
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Author: Russell H Swerdlow
Published Date October 2007
Volume 2007:2(3) Pages 347 - 359
DOI: http://dx.doi.org/10.2147/CIA.S
Russell H Swerdlow
Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA
Abstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal numerous tantalizing leads. Formulating a comprehensive AD pathogenesis theory capable of incorporating these disparate leads, though, has proven difficult. This review discusses current attempts to formulate a comprehensive AD pathogenesis theory. In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies.
Keywords: Alzheimer’s disease, aging, amyloid, cascade, mitochondria
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