skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Palonosetron as an anti-emetic and anti-nausea agent in oncology

(2395) Views  (654) Full article downloads

Authors: Matti S Aapro

Published Date January 2007 Volume 2007:3(6) Pages 1009 - 1020
DOI: http://dx.doi.org/10.2147/TCRM.S

Matti S Aapro

Clinique de Genolier, Genolier, Switzerland

Abstract: Palonosetron (Aloxi®, Onicit®, Paloxi®) is a second-generation 5-HT3 receptor antagonist (RA) with an extended half-life of ~40 hours and high binding affi nity for the 5-HT3 receptor that is markedly different from other 5-HT3 RAs. Phase III trials demonstrate that a single dose of palonosetron compared with traditional 5-HT3 RAs is more effective in preventing chemotherapy-induced nausea and vomiting (CINV) during the first 24 hours following chemotherapy (acute CINV), and also exhibits prolonged efficacy to provide significantly better protection from CINV in the delayed and overall phases. This superior and extended protection from CINV conferred by palonosetron following a single intravenous dose before chemotherapy simplifies dosing schedules. Recent research has focused on optimization of palonosetron-based antiemetic regimens, particularly in combination with steroids and neurokinin-1 RAs. The available clinical data indicate high control rates for palonosetron, suggesting a synergistic potential for protection in patients scheduled to receive emetogenic drug regimens.

Keywords: palonosetron, CINV, 5-HT3 receptor antagonists, moderately emetogenic chemotherapy (MEC), highly emetogenic chemotherapy (HEC)








Readers of this article also read:

Management of postoperative nausea and vomiting: focus on palonosetron
Prolonged rupture of membranes in term infants: should all babies be screened?
Evaluating the cost-effectiveness of tiotropium versus salmeterol in the treatment of chronic obstructive pulmonary disease
Refinement of rigid-body protein–protein docking using backbone and side-chain minimization with a coarse-grained model
One-pill once-a-day HAART: a simplification strategy that improves adherence and quality of life of HIV-infected subjects
Health literacy and health seeking behavior among older men in a middle-income nation
ABO and rhesus blood group distribution in Kurds
Corrigendum: Softec HD hydrophilic acrylic intraocular lens: biocompatibility and precision
Management of traumatic events: influence of emotion-centered coping strategies on the occurrence of dissociation and post-traumatic stress disorder
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection?