Back to Journals » Drug Design, Development and Therapy » Volume 3

Oxybutynin extended release for the management of overactive bladder: a clinical review

Authors Arisco A, Brantly E, Kraus S

Published 26 May 2009 Volume 2009:3 Pages 151—161

DOI https://doi.org/10.2147/DDDT.S3370

Review by Single anonymous peer review

Peer reviewer comments 3



AM Arisco, EK Brantly, SR Kraus

University of Texas Health Science Center at San Antonio, Department of Urology, San Antonio, Texas, USA

Abstract: Overactive bladder (OAB) is a common condition which negatively impacts the quality of life of afflicted patients. This can result in alterations in social interactions at home, in the workplace and in the community, often leading to depression and poor self esteem as well as loss of productivity. Traditional mainstays of treatment include both behavioral therapy and pharmacotherapy. Oxybutynin immediate release (IR) represents the first such medication approved by the FDA specifically for treatment of OAB in 1975. Nevertheless, bothersome side effects in addition to thrice daily dosing often led to treatment cessation which raised the question that patients may actually prefer to live with their OAB symptoms rather than incur side effects or complex dosing schemes. Pharmacological advances ultimately led to development of a long-acting formulation of oxybutynin in the form of oxybutynin extended release (ER) with the hope that this drug would maintain efficacy while decreasing bothersome side effects and improve compliance with the convenience of once daily dosing regimen. This paper will review the major clinical studies involving oxybutynin ER as well as its role in different patient populations and potential concerns with its use.

Keywords: overactive bladder, urinary urge incontinence, antimuscarinic, oxybutynin

 

Creative Commons License © 2009 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.