Overview of the pathogenesis and treatment of chronic inflammatory demyelinating polyneuropathy with intravenous immunoglobulins

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Authors: Mohamed Mahdi-Rogers, Yusuf A Rajabally

Published Date March 2010 Volume 2010:4 Pages 45 - 49

DOI: http://dx.doi.org/10.2147/BTT.S4881

Mohamed Mahdi-Rogers, Yusuf A Rajabally

Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, Leicester, UK

Abstract: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired heterogeneous disorder of immune origin affecting the peripheral nerves, causing motor weakness and sensory symptoms and signs. The precise pathophysiology of CIDP remains uncertain although B and T cell mechanisms are believed to be implicated. Intravenous immunoglobulins (IVIg) have been shown in a number of trials to be an effective treatment for CIDP. IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages and complement. This article provides an overview of the pathogenesis of CIDP and of its treatment with IVIg.

Keywords: chronic inflammatory demyelinating polyneuropathy, intravenous immunoglobulin, pathogenesis, treatment