skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Opinion - Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants

(2285) Views  (434) Full article downloads

Authors: Greg J Dusting, Chris Triggle

Published Date January 2005 Volume 2005:1(2) Pages 93 - 96
DOI: http://dx.doi.org/10.2147/VHRM.S

Greg J Dusting1, Chris Triggle2

1Howard Florey Institute, University of Melbourne, VIC, Australia; 2School of Medical Sciences, RMIT University, VIC, Australia

Are we over oxidized?

A number of recent clinical trials with antioxidants, notably vitamin C and E, have provided no support for the commonly held view that increasing our intake of antioxidants will offset the ravages of cardiovascular disease as well as other diseases (for extensive critical reviews see: Kritharides and Stocker 2002; Antoniades et al 2003; Touyz 2004). Is this conclusion justified? The role of antioxidant dietary adjuncts and therapy in prevention and treatment remains a highly important clinical question. In this opinion article we address the question: Is there a future for antioxidant therapy in the treatment and prevention of cardiovascular disease? We conclude that there is a need for better-designed studies as well as a re-thinking of the choice of antioxidants.








Readers of this article also read:

Relationship between arterial stiffness and heart rate recovery in apparently healthy adults
Optimal lipid modification: the rationale for combination therapy
Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: Effectiveness in combination with diuretics or β-blockers for treating hypertension
Ischemic preconditioning: Protection against myocardial necrosis and apoptosis
A review of the safety and efficacy of nebivolol in the mildly hypertensive patient
The pathophysiology of bronchiectasis
Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxan-induced diabetes mellitus
Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats
Erratum
Erratum
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University