Back to Browse Journals » Open Access Journal of Clinical Trials » Volume 2

Nonsurgical treatment of hemifacial microsomia by therapeutic ultrasound and hybrid functional appliance

Authors Tarek El-Bialy, Ali Hasan, Ahmad Janadas, et al

Published Date March 2010 Volume 2010:2 Pages 29—36

DOI http://dx.doi.org/10.2147/OAJCT.S7060

Published 31 March 2010

Tarek El-Bialy1, Ali Hasan2, Ahmad Janadas3, Tarik Albaghdadi4

1Division of Orthodontics, Department of Dentistry, University of Alberta, Edmonton, Alberta, Canada; 2Division of Orthodontics, Department of Preventive Dental Sciences, Faculty of Dentistry; 3Division of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry; 4Division of Radiology, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia

Aim: Conventional treatment of patients with hemifacial microsomia involves orthognathic surgery and/or distraction osteogenesis of the mandible. Previous reports showed that low-intensity pulsed ultrasound (LIPUS) enhances mandibular growth in growing rabbits and monkeys. In monkeys, LIPUS enhanced mandibular growth when combined with functional jaw orthopedic appliances. The purpose of this pilot study was to investigate if LIPUS could enhance mandibular growth in children with hemifacial microsomia.

Methods: Five children (age range 3–11 years) with hemifacial microsomia were treated with hybrid jaw orthopedic functional appliances and treatment of the affected mandibular condyle by LIPUS for 20 minutes per day.

Results: The results showed that after one year of treatment, significant improvement of the underdeveloped side of patients’ faces and mandibles was recognized both clinically and radiographically.

Discussion: Although improvement took a longer time than did a surgical approach, optimizing this technique may achieve better results in a shorter treatment time. A randomized controlled clinical trial to investigate the effect of optimized LIPUS application or functional appliances in the treatment of hemifacial microsomia is warranted.
Keywords: hemifacial microsomia, LIPUS, non-surgical treatment, children

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Novel perspectives on the origins of the hepatic myofibroblasts

Xu J, Liu X, Brenner DA, Kisseleva T

Cell Health and Cytoskeleton 2015, 7:111-119

Published Date: 20 March 2015

Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair

Liu H, Yang W, Gao H, Jiang T, Gu B, Dong Q, Xu W, Wu S, Sun X

OncoTargets and Therapy 2015, 8:509-518

Published Date: 25 February 2015

Optimal management of Ménière’s disease

Foster CA

Therapeutics and Clinical Risk Management 2015, 11:301-307

Published Date: 25 February 2015

Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

Parker AR, Petluru PN, Nienaber VL, Zhao M, Ayala PY, Badger J, Chie-Leon B, Sridhar V, Logan C, Kochat H, Hausheer FH

OncoTargets and Therapy 2015, 8:375-383

Published Date: 4 February 2015

NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/ mTOR phosphorylation

Sun ZH, Li QH, Zhang S, Chen J, Huang LL, Ren JH, Chang Y, Liang YC, Wu G

OncoTargets and Therapy 2015, 8:269-277

Published Date: 29 January 2015

Non-invasive prenatal testing: a review of international implementation and challenges

Allyse M, Minear MA, Berson E, Sridhar S, Rote M, Hung A, Chandrasekharan S

International Journal of Women's Health 2015, 7:113-126

Published Date: 16 January 2015

Optimal management of breast cancer in the elderly patient: current perspectives

Le Saux O, Ripamonti B, Bruyas A, Bonin O, Freyer G, Bonnefoy M, Falandry C

Clinical Interventions in Aging 2015, 10:157-174

Published Date: 6 January 2015

Population pharmacokinetics of olprinone in healthy male volunteers

Kunisawa T, Kasai H, Suda M, Yoshimura M, Sugawara A, Izumi Y, Iida T, Kurosawa A, Iwasaki H

Clinical Pharmacology: Advances and Applications 2014, 6:43-50

Published Date: 4 March 2014