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Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions
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Authors: Karanikas M, Machairiotis N, Zarogoulidis P, Stylianaki A, Courcoutsakis N, Mitrakas A, Touzopoulos P, Lyratzopoulos N, Kouklakis G, Spanoudakis M, Polychronidis A
Published Date December 2012
Volume 2012:5 Pages 433 - 438
|Received:||28 September 2012|
|Accepted:||06 November 2012|
|Published:||12 December 2012|
11st University Surgery Department, 2Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece; 3Pulmonary Department-Oncology Unit, G. Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Pulmonary Department-Interventional Unit, Ruhrland Clinic, University of Duisburg-Essen, Essen, Germany; 5Radiology Department, 6Endoscopy Unit, 7Hematology Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
Abstract: We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.
Keywords: hematological malignacies, mesenchymal cells, gastrointestinal cancer
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