skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients

Original Research

(2051) Views  (592) Full article downloads

Authors: Dimitrios Kourkoutas, Gerasimos Georgopoulos, Antonios Maragos, et al

Published Date April 2009 Volume 2009:3 Pages 313 - 323
DOI: http://dx.doi.org/10.2147/OPTH.S5032

Dimitrios Kourkoutas1,2, Gerasimos Georgopoulos1, Antonios Maragos1, et al

1Department of Ophthalmology, Medical School, Athens University, Athens, Greece; 2Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, Athens, Greece

Purpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma.

Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD 30 < μm), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.

Results: In the entire group, CCT was 549.78 ± 33.08 μm (range: 484–636 μm); intraocular pressure (IOP) was 16.4 ± 2.67 mmHg (range: 11–23 mmHg); MD was −3.80 ± 4.97 dB (range: 4.04 – [−20.4] dB); refraction was −0.78 ± 2.46 D (range: −6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R2 = 0.227, p < 0.01) with rim volume nasally and type of diagnosis.

Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.

Keywords: central corneal thickness, glaucoma, optic nerve head, HRT

 






Readers of this article also read:

Management of allergic conjunctivitis: an evaluation of the perceived comfort and therapeutic efficacy of olopatadine 0.2% and azelastine 0.05% from two prospective studies
Central retinal artery occlusion following severe blow-out fracture in young adult
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Comparative studies of RNFL thickness measured by OCT with global index of visual fields in patients with ocular hypertension and early open angle glaucoma
Central corneal thickness in subjects with glaucoma and in normal individuals (with or without pseudoexfoliation syndrome)
Bevacizumab (Avastin®) for the management of anterior chamber neovascularization and neovascular glaucoma
Perception of risk and benefit in patient-centered communication and care
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy