skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

New approaches in the management of multiple sclerosis

Review

(3371) Views  (1593) Full article downloads

Authors: Laurie J Barten, Douglas R Allington, Kendra A Procacci, et al

Published Date November 2010 Volume 2010:4 Pages 343 - 366
DOI: http://dx.doi.org/10.2147/DDDT.S9331

Laurie J Barten1, Douglas R Allington1, Kendra A Procacci2, Michael P Rivey1
1The University of Montana and Community Medical Center, Missoula, MT, USA; 2The University of Montana School of Pharmacy, Missoula, MT, USA

Abstract: Multiple sclerosis (MS) is a central nervous system chronic inflammatory disease that is characterized by an extensive and complex immune response. Scientific advances have occurred in immunology, pathophysiology, and diagnostic and clinical assessment tools, and recent discovery of unique therapeutic targets has spurred numerous Phase II and Phase III clinical trials. Reductions in MS relapse rates and improvements in T2 or gadolinium-enhancing lesion burdens have been reported from Phase III trials that include fingolimod, alemtuzumab, cladribine, and rituximab. Promising Phase II trial data exist for teriflunomide, daclizumab, laquinimod, and fumarate. The optimism created by these favorable findings must be tempered with evaluation of the adverse effect profile produced by these new agents. Given the discovery of progressive multifocal leukoencephalopathy with the use of natalizumab, ongoing vigilance for rare and life-threatening reactions due to new agents should be paramount. Patients with MS often experience difficulty with ambulation, spasticity, and cognition. Recent clinical trial data from two Phase III dalfampridine-SR trials indicate certain patients receive benefits in ambulation. This article provides an overview of data from clinical trials of newer agents of potential benefit in MS.

Keywords: multiple sclerosis, Phase II trials, Phase III trials, progressive multifocal leukoencephalopathy, monoclonal antibody




 

Other articles by Dr Douglas Allington



Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids
Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis
Identification of targets and new developments in the treatment of multiple sclerosis – focus on cladribine
Emerging oral treatments in multiple sclerosis – clinical utility of cladribine tablets
Evidence-based assessment of potential use of fingolimod in treatment of relapsing multiple sclerosis
Patient considerations in the management of multiple sclerosis: development and clinical utility of oral agents
Development of oral immunomodulatory agents in the management of multiple sclerosis
Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis
Patient perceptions of multiple sclerosis and its treatment
  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University