Neurologic uses of botulinum neurotoxin type A

Expert Opinion

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Authors: John P Ney, Kevin R Joseph

Published Date January 2007 Volume 2007:3(6) Pages 785 - 798

DOI: http://dx.doi.org/10.2147/NDT.S1612

John P Ney, Kevin R Joseph

Madigan Army Medical Center, Neurology Service, Tacoma, WA, USA

Abstract: This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.

Keywords: botulinum neurotoxins, BOTOX^®, Dysport^®, chemodenervation