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Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
Authors Trabelsi H, Azzouz I, Ferchichi S, Tebourbi O, Sakly M, Abdelmelek H
Received 1 June 2013
Accepted for publication 9 July 2013
Published 6 September 2013 Volume 2013:8(1) Pages 3447—3453
DOI https://doi.org/10.2147/IJN.S49323
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Hamdi Trabelsi, Inès Azzouz, Soumaya Ferchichi, Olfa Tebourbi, Mohsen Sakly, Hafedh Abdelmelek
Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia
Abstract: The aim of this study was to investigate the interaction of cadmium chloride with mineral elements in rat nephrocytes in terms of the biosynthesis of nanocomplexes. The results show that selenium supplementation enhanced cadmium accumulation in kidneys. Analysis of the fluorescence revealed an increase in red fluorescence in the kidneys of rats co-exposed to cadmium and selenium. Interestingly, X-ray diffraction measurements carried out on kidney fractions of co-exposed rats point to the biosynthesis of cadmium selenide and/or sulfide nanoparticles (about 62 nm in size). Oxidative stress assays showed the ability of selenium to reduce lipid peroxidation and to restore glutathione peroxidase and superoxide dismutase activity in kidneys. Hence, cadmium complexation with selenium and sulfur at a nanoscale level could reduce oxidative stress induced by cadmium in kidneys.
Keywords: nanoparticles, detoxification, oxidative stress, X-ray diffraction, fluorescence microscopy, kidneys
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