Mild cognitive impairment in Parkinson’s disease: the challenge and the promise || FREE PAPER ||

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Authors: Hubert H Fernandez, Gregory P Crucian, Michael S Okun, Catherine C Price, Dawn Bowers

Published Date February 2005 , Volume 2005:1(1) Pages 37 - 50 DOI 10.2147/NDT.S

Hubert H Fernandez¹, Gregory P Crucian¹, Michael S Okun¹, Catherine C Price², Dawn Bowers²

¹Department of Neurology, ²Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA

Abstract: This review addresses the literature surrounding Parkinson’s disease (PD) and mild cognitive impairment (MCI). It discusses the neuropsychological, pharmaceutical, and pathological overlap, the socioeconomic impact of PD and MCI, and the value of recognizing, understanding, and treating MCI in PD. It is concluded from this review that MCI in PD does exist and should be considered in clinical and research investigations. Due to the lack of accepted clinical criteria, an inclusive operating definition of MCI in PD is proposed. Research guidelines for studying the presence of MCI in PD and evaluating the efficacy of pharmaceutical interventions are also suggested.

Keywords: Parkinson’s, dementia, mild cognitive impairment, therapy, cognition