Back to Journals » International Journal of Women's Health » Volume 4

Mifepristone 2.5 mg versus 5 mg daily in the treatment of leiomyoma before surgery

Authors Carbonell J, Riverón AM, Cano M, Ortiz AI, Valle A, Texidó CS, Tomasi G

Received 9 November 2011

Accepted for publication 1 February 2012

Published 13 March 2012 Volume 2012:4 Pages 75—84

DOI https://doi.org/10.2147/IJWH.S28103

Review by Single anonymous peer review

Peer reviewer comments 4



Josep L Carbonell Esteve1, Ana M Riverón2, Mariela Cano2, Alma I Ortiz3, Aleta Valle2, Carlos S Texidó2, Giuseppe Tomasi4

1Mediterránea Médica Clinic, Valencia, Spain; 2Eusebio Hernández Obstetrics Teaching Hospital, Havana, Cuba; 3Alemán Hospital, Managua, Nicaragua; 4Chemistry Department, University of the Basque Country, San Sebastian, Spain

Objectives: To evaluate the efficacy and safety of 2.5 mg and 5 mg mifepristone during 3 months for the treatment of uterine fibroids before surgery.
Design: Multicenter randomized clinical trial.
Locations: Eusebio Hernández Hospital, Havana, Cuba and the Alemán Hospital, Managua, Nicaragua.
Subjects: Included in the study were 146 women with symptomatic uterine fibroids.
Treatment: Group I: half a tablet of 5 mg (2.5 mg) mifepristone taken orally every 24 hours, and Group II: one tablet of 5 mg mifepristone taken orally every 24 hours over a period of 3 months in both groups. Two endometrial biopsies were performed.
Variables to evaluate efficacy: Increase in average hemoglobin, changes in fibroid and uterine volume, and symptomatic improvement.
Results: The average hemoglobin at the end of treatment was 0.6 g/dL greater in the 5 mg mifepristone group (P = 0.033). In both groups there were similar reductions in fibroid volumes. Clinical improvement was more significant in the 5 mg group.
Conclusion: The dose to be used should be 5 mg.

Keywords: mifepristone, leiomyoma, fibroid , antiprogestins

Creative Commons License © 2012 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.