Megestrol acetate in cachexia and anorexia
Shing-Shing Yeh1, Michael W Schuster2
1Northport vAMC, Geriatric division, Northport, NY 11768; 2Weill Medical College of Cornell University and the New York Presbyterian Hospital, New York, NY 10021, USA
Abstract: The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed.
Keywords: megestrol acetate, nanocrystalline particles, cachexia