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International Journal of Nanomedicine
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Magnetic nanoparticles for gene and drug delivery
Review
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Authors: Stuart C McBain, Humphrey HP Yiu, Jon Dobson
Published Date June 2008
Volume 2008:3(2) Pages 169 - 180
DOI: http://dx.doi.org/10.2147/IJN.S1608
Stuart C McBain, Humphrey HP Yiu, Jon Dobson
Institute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, ST4 7QB, U.K.
Abstract: Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and clinical trials of drug targeting.
Keywords: magnetic nanoparticles, gene delivery, biotechnology
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