skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Long-term treatment of patients with HIV-1: the role of atazanavir

Review

(1679) Views  (581) Full article downloads

Authors: Miguel Ángel Artacho, Pablo Barreiro, José Vicente Fernández-Montero

Published Date September 2010 Volume 2010:2 Pages 157 - 166
DOI: http://dx.doi.org/10.2147/HIV.S5069

Miguel Ángel Artacho1, Pablo Barreiro2, José Vicente Fernández-Montero2
1Department of Internal Medicine, Hospital Universitario Gregorio Marañón, Madrid, Spain; 2Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain

Background: The introduction of highly-active antiretroviral therapy (HAART) remains a major milestone in the management of HIV-infected patients. Protease inhibitors (PI) are commonly used as part of triple combinations, given that to antiviral potency, better tolerance and convenience has been achieved in recent years.
Objective: To summarize and update evidence-based information about atazanavir (ATV) on initial, simplification, and rescue interventions in HIV patients.
Methods: Review of observational and randomized trials reported in medical conferences, peer-reviewed journals, and treatment guidelines.
Results: ATV is a second-generation PI, which has shown across studies potent antiviral activity and high genetic barrier, both in HAART-naïve patients or after virological failure. Indulgent metabolic profile, in terms of insulin glucose and lipid levels, adds value to this drug for the long-term management of HIV infection.

Keywords: atazanavir, HAART, protease inhibitors






Readers of this article also read:

Role of atazanavir in the treatment of HIV infection
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
The prevalence of human immunodeficiency virus infection among TB patients in Port Harcourt Nigeria
Atherosclerosis: pathogenesis and increased occurrence in individuals with HIV and Mycobacterium tuberculosis infection
Antiretroviral therapy initiated soon after HIV diagnosis as standard care: potential to save lives?
Strategies to improve HIV treatment adherence in developed countries: clinical management at the individual level
The use of preexposure treatments for HIV prophylaxis
Reproductive health options among HIV-infected persons in the low-income Niger Delta of Nigeria
Considerations in using text messages to improve adherence to highly active antiretroviral therapy: a qualitative study among clients in Yaoundé, Cameroon
New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir