Back to Browse Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 3

Long-term histological comparison between near-infrared irradiated skin and scar tissues

Authors Yohei Tanaka, Kiyoshi Matsuo, Shunsuke Yuzuriha

Published Date November 2010 Volume 2010:3 Pages 143—149

DOI http://dx.doi.org/10.2147/CCID.S15729

Published 25 November 2010

Yohei Tanaka1,2, Kiyoshi Matsuo1, Shunsuke Yuzuriha1
1Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan; 2Clinica Tanaka Plastic and Reconstructive Surgery and Anti-aging Center, Matsumoto, Japan

Background and objective: Our previous histological studies indicated that near-infrared (NIR) irradiation stimulates collagen proliferation in rat and human skin for 3 months. High collagen density in the dermis and smoothing of the epidermis were observed in irradiated rat skin, and appeared to last up to 6 months. Epidermal smoothness in irradiated rat skin seems to resemble scarring. Here, we performed a long-term histological comparison between NIR (1100 to 1800 nm) irradiated skin and scar tissues.
Materials and methods: Rat skin was irradiated using a NIR device. Scar tissues were harvested from wounded areas and were compared with irradiated skin. Histological changes up to 180 days post-treatment were evaluated with hematoxylin and eosin, Azan-Mallory staining, and collagen type I and III staining.
Results: In nonirradiated control skin, the dermis showed a low density of type I and III collagen, the surface of the epidermis was rough, and no significant changes were observed over time. In irradiated skin, both type I and III collagen increased significantly, and persisted up to 180 days. The density of type I collagen was significantly higher than that of type III collagen, whereas type I and III collagen of the control group did not differ significantly. Epidermis was thickened for 30 days, and epidermal smoothness persisted up to 180 days. In scar tissues, the density of type III collagen was higher than that of type I collagen. The number of fibroblasts remained high and the glial fibrils were dense until 180 days after injury compared with irradiated skin. Significant increases in both type I and III collagen and epidermal flattering persisted until 180 days.
Conclusions: NIR irradiation induced high collagen density in the dermis, resulting in long-term epidermal smoothness without scar formation. Results indicated that NIR irradiation provides safe, consistent, and long-term effects of skin rejuvenation.

Keywords: near-infrared irradiation, long-term effects, collagen, scar, skin rejuvenation

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Objective assessment of skin rejuvenation using near-infrared 1064-nm neodymium: YAG laser in Asians

Tanaka Y, Matsuo K, Yuzuriha S

Clinical, Cosmetic and Investigational Dermatology 2011, 4:123-130

Published Date: 27 July 2011

Readers of this article also read:

Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses

Hideki Hasegawa, Takeshi Ichinohe, Akira Ainai, Shin-ichi Tamura, Takeshi Kurata

Therapeutics and Clinical Risk Management 2009, 5:125-132

Published Date: 9 March 2009

Smoking cessation: an economic analysis and review of varenicline

Michele A Faulkner

ClinicoEconomics and Outcomes Research 2009, 1:25-34

Published Date: 24 June 2009

Management of hypotrichosis of the eyelashes: Focus on bimatoprost

Steven Fagien

Clinical, Cosmetic and Investigational Dermatology 2010, 3:39-48

Published Date: 13 April 2010

Lyme disease: the next decade

Raphael B Stricker, Lorraine Johnson

Infection and Drug Resistance 2011, 4:1-9

Published Date: 7 January 2011

Objective assessment of skin rejuvenation using near-infrared 1064-nm neodymium: YAG laser in Asians

Tanaka Y, Matsuo K, Yuzuriha S

Clinical, Cosmetic and Investigational Dermatology 2011, 4:123-130

Published Date: 27 July 2011

Mitochondrial disorders and the eye

Van Bergen NJ, Chakrabarti R, O’Neill EC, Crowston JG, Trounce IA

Eye and Brain 2011, 3:29-47

Published Date: 27 September 2011

The discrediting of the monoamine hypothesis

Hinz M, Stein A, Uncini T

International Journal of General Medicine 2012, 5:135-142

Published Date: 14 February 2012

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Characterization and evolution of dermal filaments from patients with Morgellons disease

Middelveen MJ, Mayne PJ, Kahn DG, Stricker RB

Clinical, Cosmetic and Investigational Dermatology 2013, 6:1-21

Published Date: 8 January 2013