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Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel

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Authors: Abdalla Bowirrat, Jing Cui, Kristin Waraska, Robert P Friedland, Marlene Oscar-Berman, Lindsay A Farrer, Amos Korczyn, Clinton T Baldwin

Published Date February 2005 Volume 2005:1(1) Pages 73 - 76
DOI: http://dx.doi.org/10.2147/NDT.S

Abdalla Bowirrat1,2,3, Jing Cui4, Kristin Waraska5, Robert P Friedland10, Marlene Oscar-Berman2,3,6, Lindsay A Farrer1,6,7,8,9, Amos Korczyn11, Clinton T Baldwin1,5,7

1Genetic Program, 2Department of Anatomy and Neurobiology, 3Division of Psychiatry, 4Hypertension Section, 5Center for Human Genetics, 6Department of Neurology, 7Department of Genetics and Genomics, Boston University School of Medicine, Boston, MA, USA; 8Department of Epidemiology, 9Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; 10Department of Neurology, Case Western Reserve University, Cleveland, OH, USA; 11Department of Neurology, Tel Aviv University, Tel Aviv, Israel

Abstract: The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer’s disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer’s type (DAT) in an Arab–Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD).

Keywords: angiotensin-converting enzyme, dementia of the Alzheimer’s type, age-related cognitive decline, insertion–deletion polymorphism, Arab population