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Back to Archived Journals » Journal of Receptor, Ligand and Channel Research » Volume 8

Journal of Receptor, Ligand and Channel Research ceased publishing in November 2018. All articles that have been published in Journal of Receptor, Ligand and Channel Research will continue to be available on the Dove Press site, and will be securely archived with CLOCKSS.

ESCI

Journal of Receptor, Ligand and Channel Research

ISSN: 1178-699X

Archive: Volume 8, 2015

Review

Noteworthy comment: The search for effective but safe anti-depressant drugs continues in parallel with studies of dietary influences and the use of lifestyle factors such as exercise. In this short review Rodrigues and colleagues summarise key findings on these topics and draw together the evidence that they may act via a common pathway known as mTOR (mammalian Target Of Rapamycin). A more intensive investigation into this target could yield the more selective and useful drugs that are urgently needed

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mTOR signaling in the neuropathophysiology of depression: current evidence

Réus GZ, Quevedo J, Rodrigues AL

Journal of Receptor, Ligand and Channel Research 2015, 8:65-74

Published Date: 23 November 2015

Review

Noteworthy comment: Voltage-gated ion channels are important factors in determining tissue excitability and are increasingly seen as potential targets for the treatment of new drugs in disorders such as epilepsy and cardiac dysfunction. This review focusses on the regulation of several varieties of voltage-gated channels, including sodium, potassium and chloride channels as well as related proteins, by the E3 ubiquitin ligase Nedd4-2. As such this is a novel and valuable summary and perspective of a rapidly growing field. It also serves to emphasise the potential therapeutic value of targeting new drugs on molecules that regulate channel function in addition to the channels themselves.

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Nedd4-2 regulation of voltage-gated ion channels: an update on structure–function relationships and the pathophysiological consequences of dysfunction

Arévalo JC

Journal of Receptor, Ligand and Channel Research 2015, 8:53-63

Published Date: 18 August 2015

Original Research

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mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel

Huang TQ, Zou MX, Pasek DA, Meissner G

Journal of Receptor, Ligand and Channel Research 2015, 8:43-51

Published Date: 20 May 2015

Review

Noteworthy comment: Despite the availability of several classes of drugs, migraine remains a difficult condition to treat effectively. This review provides an overview of three compounds : calcitonin gene related peptide (CGRP), brain natriuretic peptide (BNP) and ATP, whose intricate interactions contributes to the regulation of those neurons in the trigeminal system which generate the severe pain and other symptoms of migraine. Developing our knowledge of these compounds could lead to the generation of increasingly more effective drugs for the treatment of the condition.

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Role of calcitonin gene-related peptide and brain natriuretic peptide to modulate the excitability state of trigeminal neurons: relevance to migraine pathology and treatment

Vilotti S, Fabbretti E, Nistri A

Journal of Receptor, Ligand and Channel Research 2015, 8:31-41

Published Date: 19 January 2015

Review

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Phosphodiesterase inhibition in the treatment of autoimmune and inflammatory diseases: current status and potential

Miller MS

Journal of Receptor, Ligand and Channel Research 2015, 8:19-30

Published Date: 23 December 2014

Review

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Pentameric viral ion channels: from structure to function

Surya W, Li Y, Torres J

Journal of Receptor, Ligand and Channel Research 2015, 8:9-18

Published Date: 22 December 2014

Review

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Programmed death-1/programmed death-1 ligand axis as a therapeutic target in oncology: current insights

Schalper KA, Venur VA, Velcheti V

Journal of Receptor, Ligand and Channel Research 2015, 8:1-7

Published Date: 23 December 2014