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Back to Archived Journals » Journal of Receptor, Ligand and Channel Research » Volume 7

Journal of Receptor, Ligand and Channel Research ceased publishing in November 2018. All articles that have been published in Journal of Receptor, Ligand and Channel Research will continue to be available on the Dove Press site, and will be securely archived with CLOCKSS.

ESCI

Journal of Receptor, Ligand and Channel Research

ISSN: 1178-699X

Archive: Volume 7, 2014

Review

Highly-accessed

Pharmacophore modeling: advances, limitations, and current utility in drug discovery

Qing XY, Lee XY, De Raeymaeker J, Tame JRH, Zhang KYJ, De Maeyer M, Voet ARD

Journal of Receptor, Ligand and Channel Research 2014, 7:81-92

Published Date: 11 November 2014

Review

Noteworthy Comment: The growth factor Brain-Derived Neurotrophic Factor (BDNF) has long been established as playing a crucial role in brain development, function and plasticity. This review covers many of these aspects and the role of BDNF in a range of disorders including schizophrenia, depression and inflammation-driven disorders of the CNS.

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BDNF–TrkB signaling as a therapeutic target in neuropsychiatric disorders

Du X, Wu YC, Hill RA

Journal of Receptor, Ligand and Channel Research 2014, 7:61-79

Published Date: 6 October 2014

Review

Noteworthy Comment: Potassium channels are being increasingly recognised as critical contributors to the physiological regulation of tissue function and to several major disorders. They have for many years been the target for drugs in the treatment of some conditions such as hypertension. This review provides a concise but timely and focussed review of the role of potassium channels specifically in the control of vascular tone and should stimulate further work and new drug development in this area

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K+ channels in biological processes: vascular K+ channels in the regulation of blood pressure

Werner ME, Ledoux J

Journal of Receptor, Ligand and Channel Research 2014, 7:51-60

Published Date: 30 September 2014

Review

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The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence

Hanada T

Journal of Receptor, Ligand and Channel Research 2014, 7:39-50

Published Date: 18 September 2014

Review

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Structure-based three-dimensional pharmacophores as an alternative to traditional methodologies

Gaurav A, Gautam V

Journal of Receptor, Ligand and Channel Research 2014, 7:27-38

Published Date: 12 June 2014

Review

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Adipokines: biological functions and metabolically healthy obese profile

Pereira SS, Alvarez-Leite JI

Journal of Receptor, Ligand and Channel Research 2014, 7:15-25

Published Date: 15 May 2014

Review

Noteworthy Comment: The large conductance calcium and voltage-gated potassium channels (BK-Ca) are present in most tissues and regulate a wide range of physiological functions. This review summarises the structure, molecular interactions and functional roles of these crucial channels as well as their potential involvement in disease states.

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BKCa channels as physiological regulators: a focused review

Vetri F, Choudhury MSR, Pelligrino DA, Sundivakkam P

Journal of Receptor, Ligand and Channel Research 2014, 7:3-13

Published Date: 31 March 2014

Corrigendum

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Interaction of recombinant and native Cav2.3 E-/R-type voltage-gated Ca2+ channels with the molecular chaperone Hsp70 [Corrigendum]

Radhakrishnan K, Krieger A, Tevoufouet EE, Dietz GP, Nagel F, Bähr M, Hescheler J, Schneider T

Journal of Receptor, Ligand and Channel Research 2014, 7:1-2

Published Date: 17 January 2014