Is there an optimal management for localized prostate cancer?
Jaspreet Singh , Edouard J Trabulsi, Leonard G Gomella
Department of Urology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA, USA
Abstract: Widespread screening with prostate-specific antigen (PSA) has led to a significant increase in the detection of early stage, clinically localized prostate cancer (CaP). Various treatment options for localized CaP are discussed in this review article including active surveillance, radical prostatectomy, radiation therapy, and cyrotherapy. The paucity of high-level evidence adds a considerable amount of controversy when choosing the “optimal” intervention, for both the treating physician and the patient. The long time course of CaP intervention outcomes, combined with continuing modifications in treatments, further complicate the matter. Lacking randomized trials that compare treatment options, this review article attempts to summarize the different treatment options and associated side-effects, including effects on health-related quality of life, from current published literature.
Keywords: prostate cancer, PSA, detection
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Readers of this article also read:
Performance of PLS regression coefficients in selecting variables for each response of a multivariate PLS for omics-type data
Giuseppe Palermo, Paolo Piraino, Hans-Dieter Zucht
Published Date: 13 May 2009
Noll Campbell, Malaz Boustani, Tony Limbil, Carol Ott, et al.
Published Date: 13 May 2009
Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies
Kevin J Ruff, Dale P DeVore, Michael D Leu, Mark A Robinson
Published Date: 18 May 2009
Dimitris Papaconstantinou, Ilias Georgalas, Nikos Kourtis, et al.
Published Date: 24 July 2009
Minoru Yamaoka, Yusuke Ono, Masahiro Takahashi, et al
Published Date: 31 July 2009
Alfonso Merante, Pietro Gareri, Norma Maria Marigliano, et al
Published Date: 25 March 2010
Alberto Goldman, Uwe Wollina
Published Date: 14 September 2010
Helena A Figueira, Olivia A Figueira, Alan A Figueira, et al
Published Date: 1 October 2010
Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine
Duncan RS, Xin H, Goad DL, Chapman KD, Koulen P
Published Date: 26 April 2011
Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi
Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M, Stricker RB
Published Date: 3 May 2011