skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Is obesity in women protective against osteoporosis?

Review

(2762) Views  (678) Full article downloads

Authors: Migliaccio S, Greco EA, Fornari R, Donini LM, Lenzi A

Published Date July 2011 Volume 2011:4 Pages 273 - 282
DOI: http://dx.doi.org/10.2147/DMSO.S11920

Silvia Migliaccio1,2, Emanuela A Greco1, Rachele Fornari1, Lorenzo M Donini1, Andrea Lenzi1
1Dipartimento di Medicina Sperimentale, Sezione di Fisiopatologia, Endocrinologia e Nutrizione, Università Sapienza di Roma, 2Dipartimento di Scienze della Salute, Università Foro Italico di Roma, Italia

Abstract: The belief that obesity is protective against osteoporosis has recently come into question. The latest epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Further, increasing evidence seems to indicate that different components of the metabolic syndrome, ie, hypertension, increased triglycerides, reduced high-density lipoprotein cholesterol, are also potential risk factors for the development of low bone mineral density and osteoporosis. This review considers both the older and more recent data in the literature in order to evaluate further the relationship between fat tissue and bone tissue.

Keywords: bone mineral density, fat mass, body mass index, fractures, adipocytes




 

Other articles by Dr Silvia Migliaccio



Readers of this article also read:

Management of glucocorticoids-induced osteoporosis: role of teriparatide
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
Strategy to combat obesity and to promote physical activity in Arab countries
Is vitamin D status a determining factor for metabolic syndrome? A case-control study
Efficacy and safety of bazedoxifene for postmenopausal osteoporosis
Effect of weight loss on adipokine levels in obese patients
Safety and tolerability of denosumab for the treatment of postmenopausal osteoporosis
Negative association of acetate with visceral adipose tissue and insulin levels
Clinical features and treatment of maturity onset diabetes of the young (MODY)
  • Testimonials

    "You do a tremendous job!!" Ruben Restrepo, The University of Texas Health Science Center at San Antonio