skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Intravenous clevidipine for management of hypertension

Review

(1523) Views  (553) Full article downloads

Authors: Alma Rivera, Elsa Montoya, Joseph Varon

Published Date June 2010 Volume 2010:3 Pages 105 - 111
DOI: http://dx.doi.org/10.2147/IBPC.S6536

Alma Rivera1, Elsa Montoya2, Joseph Varon3

1Universidad Autónoma de Chihuahua, Chihuahua, México; 2Universidad de Monterrey, Nuevo León, México; 3University of Texas Health Science Center at Houston, Texas, USA

Abstract: Hypertension remains one of the most prevalent diseases affecting our society, and its complications lead the list of causes of mortality all over the world. Most efforts to control the disease are unsuccessful, failing in at least two-thirds of affected patients, despite the availability of multiple drugs for its treatment. The limited number of medications available for aggressive management of hypertensive crises has intensified the search for novel drugs that can achieve a rapid decrease in blood pressure without increasing the possible complications. Clevidipine is a novel, vasculoselective, dihydropyridine calcium channel blocker characterized by a very fast onset and offset of action. Metabolism of clevidipine does not occur in the liver or kidneys, and thus there are no restrictions to using clevidipine in patients with hepatic or renal dysfunction. This agent has been widely used to reduce blood pressure when oral therapy is not appropriate, and its use in the perioperative setting has been shown to be beneficial. This manuscript reviews the key characteristics of clevidipine and its role in the management of acute hypertension.

Keywords: clevidipine, hypertension management, acute, hypertensive crises, intravenous








Readers of this article also read:

Antihypertensive effects of astaxanthin
Impact of dyslipidemia on cardiovascular risk stratification of hypertensive patients and association of lipid profile with other cardiovascular risk factors: results from the ICEBERG study
Cuff inflation during ambulatory blood pressure monitoring and heart rate
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Critical appraisal of amlodipine and olmesartan medoxomil fixed-dose combination in achieving blood pressure goals
Functional mobility and balance in community-dwelling elderly submitted to multisensory versus strength exercises
Perception of risk and benefit in patient-centered communication and care
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy
  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University