Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis

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Authors: Tsuneyoshi Ka, Yuji Moriwaki, Takeshi Nakanishi, Tetsuya Yamamoto

Published Date June 2008 Volume 2008:1 Pages 1 - 2

DOI: http://dx.doi.org/10.2147/DMSO.S3588

Tsuneyoshi Ka¹, Yuji Moriwaki¹, Takeshi Nakanishi², Tetsuya Yamamoto¹

Divisions of ¹Endocrinology and Metabolism, and ²Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

Abstract: The patient, a 66-year-old woman, who has been under hemodialysis due to antineutrophil cytoplasm autoantibody (ANCA)-associated glomerulonephritis since 2003, was hospitalized because of cold sweating, general fatigue, and somnolence. Hypoglycemia (43 mg/dL) with markedly elevated insulin level (1410 µU/mL) and insulin antibody was found in her serum. She was diagnosed as having insulin autoimmune syndrome. She has not taken any medication that might cause insulin autoimmune syndrome. The possible association of ANCA-associated glomerulonephritis with insulin autoimmune syndrome is discussed.

Keywords: hypoglycemia, insulin antibody, ANCA, insulin autoimmune syndrome