Back to Browse Journals » Journal of Inflammation Research » Volume 3

Inflammatory cytokines and atrial fibrillation: current and prospective views

Authors Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, et al.

Published Date August 2010 Volume 2010:3 Pages 75—97

DOI http://dx.doi.org/10.2147/JIR.S10095

Published 30 August 2010

Hadi AR Hadi, Alawi A Alsheikh-Ali, Wael AL Mahmeed, Jassim M Al Suwaidi

Institute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates

Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and a ­challenging clinical problem encountered in daily clinical practice. There is an increasing body of evidence linking inflammation to a broad spectrum of cardiovascular conditions including AF. Historical evidence supports an association between AF and inflammation and is consistent with the association of AF with inflammatory conditions of the heart, such as myocarditis and pericarditis. AF has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. Increased plasma interleukin (IL)-6, C-reactive protein (CRP), and plasma viscosity support the existence of an inflammatory state among “typical” populations with chronic AF. These indexes of inflammation are related to the prothrombotic state and may be linked to the clinical characteristics of the patients (underlying vascular disease and comorbidities), rather than simply to the presence of AF itself. It has been suggested that inflammation may have a role in the development of atrial arrhythmias after cardiac surgery, and that a genetic predisposition to develop postoperative complications exists. Cytokines can have a prognostic significance; IL-6 levels, CRP, and other cytokines may have prognostic value in AF. Cytokine lowering therapies, statins, angiotensin converting enzyme inhibitors and other anti-inflammatory agents may have a role in the treatment of AF. The present article provides an overview of the evidence linking inflammatory cytokines to AF and their therapeutic and prognostic implications.

Keywords: atrial fibrillation, inflammation, cytokines

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Pleiotropic effects of statins in atrial fibrillation patients: the evidence

Hadi AR Hadi, Wael Al Mahmeed, Jassim Al Suwaidi, Samer Ellahham

Vascular Health and Risk Management 2009, 5:533-551

Published Date: 17 June 2009

Readers of this article also read:

A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system

Eroglu E, Tiwari PM, Waffo AB, Miller ME, Vig K, Dennis VA, Singh SR

International Journal of Nanomedicine 2013, 8:1403-1415

Published Date: 11 April 2013

Pattern sensitivity: a missed part of the diagnosis

El Shakankiry HM, Abdel Kader AA

Neuropsychiatric Disease and Treatment 2012, 8:313-319

Published Date: 17 July 2012

Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study

Rinaldi S, Maioli M, Santaniello S, Castagna A, Pigliaru GF, Gualini S, Margotti ML, Carta A, Fontani V, Ventura C

Clinical Interventions in Aging 2012, 7:191-194

Published Date: 29 June 2012

Gelatinase-stimuli strategy enhances the tumor delivery and therapeutic efficacy of docetaxel-loaded poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles

Liu Q, Li RT, Qian HQ, Yang M, Zhu ZS, Wu W, Qian XP, Yu LX, Jiang XQ, Liu BR

International Journal of Nanomedicine 2012, 7:281-295

Published Date: 20 January 2012

Psychotherapy and medication management strategies for obsessive-compulsive disorder

Walsh KH, McDougle CJ

Neuropsychiatric Disease and Treatment 2011, 7:485-494

Published Date: 23 August 2011

A case of recurrent bloody tears

Karslıoğlu Ş, Şimşek İB, Akbaba M

Clinical Ophthalmology 2011, 5:1067-1069

Published Date: 29 July 2011

Radiation therapy for neovascular age-related macular degeneration

Robert Petrarca, Timothy L Jackson

Clinical Ophthalmology 2011, 5:57-63

Published Date: 10 January 2011

Prevention strategies for antimicrobial resistance: a systematic review of the literature

Whitney P Caron, Shaker A Mousa

Infection and Drug Resistance 2010, 3:25-33

Published Date: 21 May 2010

Methicillin-resistant Staphylococcus epidermidis isolation from the vitrectomy specimen four hours after initial treatment with vancomycin and ceftazidime

Golnaz Javey, Stephen G Schwartz, Andrew A Moshfeghi, et al

Clinical Ophthalmology 2010, 4:101-104

Published Date: 25 February 2010