Incidence and survival differences of differentiated thyroid cancer among younger women

Melissa M Boltz,¹ Laura M Enomoto,^1,2 Rollyn M Ornstein,³ Brian D Saunders,^1,4 Christopher S Hollenbeak<sup>1,2,5

1</sup>Department of Surgery, ²Division of Outcomes Research and Quality, The Pennsylvania State University, College of Medicine, ³Department of Pediatrics, Division of Adolescent Medicine and Eating Disorders, The Pennsylvania State University, Hershey Children’s Hospital, ⁴Division of General Surgery Specialties and Surgical Oncology, ⁵Department of Public Health Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA


Abstract: Differentiated thyroid cancer is the most common endocrine malignancy, with an estimated 60,220 new cases diagnosed in the United States in 2013. For reasons that are unclear, differentiated thyroid cancer is three times more common in females than in males. However, among adolescent and young adult females between ages 15–39 years, differentiated thyroid cancer remains under-recognized. The disparity in cancer incidence and outcomes in this population may be secondary to the tumor's biology, and risk factors unique to women. This review summarizes the incidence and survival rates of thyroid cancer in women younger than 45 years of age, as well as the pathophysiology, etiology, risk factors, prognosis, and current and emerging treatment options for this patient population.

Keywords: differentiated thyroid cancer, young adult women, adolescents, incidence, risk factors, treatment