Back to Browse Journals » International Journal of Women's Health » Volume 5

Improved compliance and patient satisfaction with estradiol vaginal tablets in postmenopausal women previously treated with another local estrogen therapy

Authors Minkin MJ, Maamari R, Reiter S

Published Date March 2013 Volume 2013:5 Pages 133—139

DOI http://dx.doi.org/10.2147/IJWH.S41897

Received 20 December 2012, Accepted 1 February 2013, Published 15 March 2013

Mary Jane Minkin,1 Ricardo Maamari,2 Suzanne Reiter3

1Obstetrics, Gynecology, and Menopause, Temple Medical Center, New Haven, CT, 2Hormone Therapy, Novo Nordisk Inc, Princeton, NJ, 3Mid-County Health Center, Largo, FL, USA

Abstract: Up to half of all postmenopausal women will experience changes in the genitourinary tract induced by the hypoestrogenic state, collectively known as vaginal atrophy. Vaginally administered local estrogen therapy (LET) is the standard of care for symptoms of vaginal atrophy that do not respond to nonhormonal interventions. Several LET formulations are available, and choice of therapy is based largely on patient needs and preferences. This online survey of postmenopausal LET users was conducted to investigate reasons for switching to vaginal estradiol tablets from other formulations and to evaluate factors associated with patient preference for and compliance with use of LET. Data was analyzed from 73 respondents currently using estradiol vaginal tablets who have previously used the estradiol vaginal ring, estradiol vaginal cream, and/or conjugated estrogen vaginal cream. Patients in this survey rated vaginal symptoms of vaginal atrophy as being more bothersome than urinary symptoms. Respondents preferred their current treatment with the vaginal tablet to their previous treatment with a cream or ring. The preference for tablets over creams was mainly related to formulation and application rather than to any perceived safety issues. Tablets were perceived as efficacious, convenient, and neat to apply. The study participants also reported a longer duration of tablet use compared with creams or rings, and greater compliance with vaginal tablets than with vaginal cream. This study provides new insights into reasons for patient noncompliance with estrogen cream or ring therapy that can be used to maximize patient adherence with LET.

Keywords: vaginal atrophy, local estrogen therapy, estradiol, vaginal ring, vaginal tablet, vaginal cream, conjugated estrogen vaginal cream

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Burden of vasomotor symptoms in France, Germany, Italy, Spain, and the United Kingdom

DiBonaventura MD, Chandran A, Hsu MA, Bushmakin A

International Journal of Women's Health 2013, 5:261-269

Published Date: 24 May 2013

Women’s awareness and periconceptional use of folic acid: data from a large European survey

Bitzer J, von Stenglin A, Bannemerschult R

International Journal of Women's Health 2013, 5:201-213

Published Date: 26 April 2013

Changes in cervical cancer screening behavior for women attending Pap Test Week clinics

Poliquin V, Decker K, Altman AD, Lotocki R

International Journal of Women's Health 2013, 5:141-148

Published Date: 8 April 2013

Safety and effectiveness of different dosage of mifepristone for the treatment of uterine fibroids: a double-blind randomized clinical trial

Carbonell JL, Acosta R, Perez Y, Marrero AG, Trellez E, Sanchez C, Tomasi G

International Journal of Women's Health 2013, 5:115-124

Published Date: 19 March 2013

Noninvasive screening tools for Down syndrome: a review

Smith M, Visootsak J

International Journal of Women's Health 2013, 5:125-131

Published Date: 6 March 2013

Outcomes in hypertensive disorders of pregnancy in the North Indian population

Sachan R, Patel ML, Sachan P, Gaurav A, Singh M, Bansal B

International Journal of Women's Health 2013, 5:101-108

Published Date: 6 March 2013