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Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
Original Research
(3329) Views (605) Full article downloads
Authors: Tam Ly, Jyoti Gulia, Vasilios Pyrgos, Masashi Waga, Shmuel Shoham
Published Date June 2008
Volume 2008:4(3) Pages 637 - 640
DOI: http://dx.doi.org/10.2147/TCRM.S2838
Tam Ly, Jyoti Gulia, Vasilios Pyrgos, Masashi Waga, Shmuel Shoham
Section of Infectious Diseases, Washington Hospital Center, Washington DC, USA
Abstract: Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notifi cation was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges.
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