Back to Browse Journals » Neurobehavioral HIV Medicine » Volume 2

Impact of COMT Val158Met on executive functioning in the context of HIV and methamphetamine

Authors Chad A Bousman, Mariana Cherner, Stephen J Glatt, et al

Published Date January 2010 Volume 2010:2 Pages 1—11

DOI http://dx.doi.org/10.2147/NBHIV.S8245

Published 14 January 2010

Chad A Bousman1, Mariana Cherner1, Stephen J Glatt2, J Hampton Atkinson1, Igor Grant1, Ming T Tsuang1, Ian P Everall1

1Department of Psychiatry, University of California San Diego, La Jolla, California, USA; 2Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY, USA

Abstract: The catechol-O-methyltransferease (COMT) Val allele has been linked to executive dysfunction among healthy individuals. The nature of this relationship is unknown in the context of HIV infection and/or methamphetamine (METH) dependence, two conditions that can alter dopaminergic system functioning. We sought to determine if the putative relationship between COMT and executive dysfunction could be observed among individuals with and without HIV-infection and/or METH dependence, and to explore the specificity of this relationship by examining other cognitive domains. Utilizing an existing cohort of 229 men with and without HIV infection and/or METH dependence we found that Met/Met carriers within the HIV-only and control groups, displayed better executive functioning compared to Val/Val and Val/Met carriers. However, this effect was attenuated in the METH-only and comorbid (ie, HIV+/METH+) groups. Examination of other neurocognitive domains were not consistent with effects found for executive functioning. Results support the presumed neuroprotective effect of Met/Met genotype on executive functioning among HIV-only and control groups. Among METH-only and comorbid groups, the slower rate of dopamine clearance conferred by the Met/Met genotype may increase the risk of adverse effects of METH, resulting in comparable executive dysfunction to that of Val allele carriers.
Keywords: Val158Met, Endophenotype, Executive Function

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Exploration of a genomic expression and pathway analysis approach to neurocognitive performance: preliminary findings

Chad A Bousman, Gursharan Chana, Stephen J Glatt, et al

Neurobehavioral HIV Medicine 2010, 2:23-32

Published Date: 12 July 2010

Readers of this article also read:

Hearing aid fitting in older persons with hearing impairment: the influence of cognitive function, age, and hearing loss on hearing aid benefit

Meister H, Rählmann S, Walger M, Margolf-Hackl S, Kießling J

Clinical Interventions in Aging 2015, 10:435-443

Published Date: 10 February 2015

Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy

Schaffran T, Jiang N, Bergmann M, Küstermann E, Süss R, Schubert R, Wagner FM, Awad D, Gabel D

International Journal of Nanomedicine 2014, 9:3583-3590

Published Date: 29 July 2014

Deposit buildup on prosthetic eye material (in vitro) and its effect on surface wettability

Pine KR, Sloan B, Han KYI, Swift S, Jacobs RJ

Clinical Ophthalmology 2013, 7:313-319

Published Date: 13 February 2013

Ability of a neuro-ophthalmologist to estimate retinal nerve fiber layer thickness

Pula JH, Kattah JC, Wang H, Marshall J, Eggenberger ER

Clinical Ophthalmology 2012, 6:1477-1481

Published Date: 11 September 2012

The effect of phacoemulsification on late bleb failure or intraocular pressure in patients with glaucoma: a systematic review

Peponis VG, Chalkiadakis SE, Katzakis MC, Parikakis EA

Clinical Ophthalmology 2012, 6:1045-1049

Published Date: 6 July 2012

Immune activation and neuropsychiatric symptoms in human immunodeficiency virus type 1 infection

Schroecksnadel S, Kurz K, Weiss G, Fuchs D

Neurobehavioral HIV Medicine 2012, 4:1-13

Published Date: 16 January 2012

GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?

Young RP, Hopkins RJ, Hay BA, Gamble GD

The Application of Clinical Genetics 2011, 4:137-144

Published Date: 13 September 2011

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Eduardo Pimenta, Suzanne Oparil

Vascular Health and Risk Management 2009, 5:453-463

Published Date: 19 May 2009