skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Identification and reduction of adverse drug reactions

Review

(1359) Views  (591) Full article downloads

Authors: Dennis F Thompson, Randall P Sharp

Published Date July 2010 Volume 2010:2 Pages 43 - 48
DOI: http://dx.doi.org/10.2147/JHL.S8022

Southwestern Oklahoma

State University, Weatherford, Oklahoma, USA

Abstract: Adverse drug reactions (ADRs) are a significant challenge to health care leaders. Serious ADRs increase the morbidity and mortality of patients and create a significant financial impact on health care costs. There are a number of challenges in identifying and reducing the incidence of ADRs. Worldwide, developed countries primarily utilize voluntary systems to identify ADRs and assess their risk to specific populations of patients. All of these systems have significant limitations. The explosion of biomedical research also challenges the clinician to uncover all the literature available concerning particular ADRs. Once identified, assessing causality in a specific patient-drug scenario can be problematic despite the number of scales, algorithms, and nomograms available. Finally, pharmacogenomics is discussed and the implications of personalized genomic medicine on ADRs are described. Pharmacogenomics promises the best possible hope for a significant reduction of clinically important ADRs in the future, although hurdles remain for its’ widespread clinical application.

Keywords: adverse drug reactions, surveillance, pharmacogenomics






Readers of this article also read:

Professional and career issues in administrative medicine
Leadership insights of the Chinese military classics: for physician leaders and healthcare administrators
Leadership for health care in the 21st Century: A personal perspective
Development of indicators for identifying adverse drug events in an Indian tertiary care teaching hospital
Entice, engage, endure: adapting evidence-based retention strategies to a new generation of nurses
Academic leadership searches: evolving best practices
Perspectives on healthcare leader and leadership development
A vision and compass for healthcare leadership: Lessons from the migrant nurse resolution for recurrent nursing shortages
Pharmacist characteristics, medication use perceptions, and professional satisfaction: a first national survey in the state of Qatar
The occurrence of adverse drug reactions reported for attention deficit hyperactivity disorder (ADHD) medications in the pediatric population: a qualitative review of empirical studies