skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease

Review

(2906) Views  (764) Full article downloads

Authors: Navin K Kapur, Dominique Ashen, Roger S Blumenthal

Published Date March 2008 Volume 2008:4(1) Pages 39 - 57
DOI: http://dx.doi.org/10.2147/VHRM.S1940

Navin K Kapur, Dominique Ashen, Roger S Blumenthal

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract: Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein cholesterol (HDL-C) and its relationship to coronary heart disease (CHD) has grown substantially. Numerous clinical trials since the Framingham Study in 1977 have demonstrated an inverse relationship between HDL-C and one’s risk of developing CHD. Over the past two decades, preclinical research has gained further insight into the nature of HDL-C metabolism, specifically regarding the ability of HDL-C to promote reverse cholesterol transport (RCT). Recent attempts to harness HDL’s ability to enhance RCT have revealed the complexity of HDL-C metabolism. This review provides a detailed update on HDL-C as an evolving therapeutic target in the management of cardiovascular disease.

Keywords: high density lipoprotein cholesterol (HDL-C), coronary, atherosclerosis, reverse cholesterol transport






 

Other articles by Dr N Kapur



Readers of this article also read:

Comprehensive cardiovascular risk management – what does it mean in practice?
Correlation of microalbumin and sialic acid with anthropometric variables in type 2 diabetic patients with and without nephropathy
Endothelial effects of antihypertensive treatment: focus on irbesartan
Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians
Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk
Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility
Editorial
Improvement of adenoviral vector-mediated gene transfer to airway epithelia by folate-modified anionic liposomes
Corrigendum
Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University