Health-related quality of life in outpatients with COPD in daily practice: the VICE Spanish study

Original Research

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Authors: Antonio Martín, José M Rodríguez-González Moro, José L Izquierdo, Elena Gobartt, Pilar de Lucas, The VICE Study Group

Published Date December 2008 Volume 2008:3(4) Pages 683 - 692

DOI: http://dx.doi.org/10.2147/COPD.S4791

Antonio Martín¹, José M Rodríguez-González Moro², José L Izquierdo³, Elena Gobartt⁴, Pilar de Lucas², The VICE Study Group

¹Medical Department, Pfizer, Madrid, Spain; ²Service of Pneumology, HGU Gregorio Marañón, Madrid, Spain; ³Service of Pneumology, Hospital General Universitario de Guadalajara, Guadalajara, Spain; ⁴Respiratory Area, Medical Department, Boehringer Ingelheim España, Madrid, Spain

Background: The objective of this study was to measure health-related quality of life (HRQL) in outpatients with chronic obstructive pulmonary disease (COPD) and to assess differences in HRQL according to age, gender, and severity of COPD.

Methods: A total of 9405 patients (79% men, mean age 68 years) participated in a cross-sectional study. HRQL was measured with the Short Form 12 Health Survey Questionnaire (SF-12). Severity of COPD was graded into three levels according to forced expiratory volume in one second value.

Results: COPD severity was mild in 33.8% of cases, moderate in 49.3% and severe in 16.8%. The mean physical component summary (PCS-12) and mental component summary (MCS-12) scores were 36.8 ± 10.4 and 47.2 ± 11.2, respectively. General health and physical functioning domains were those with the lowest scores. The mean MCS-12 scores were significantly higher in men (47.9 ± 10.9) than in women (44.1 ± 11.8) (P < 0.001). Patients older than 60 years rated HRQL worse than patients aged 40–59 years. There were statistically significant differences according to severity of disease in the mean scores of all domains of the PCS-12 and MCS-12 scales.

Conclusions: The present findings show the influence of female gender, older age and moderate-to-severe of airflow limitation on HRQL in outpatients with COPD attended in daily practice.

Keywords: health status, health surveys, multicenter study, pulmonary disease, chronic obstructive/epidemiology, quality of life, questionnaires

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