skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats

(4323) Views  (774) Full article downloads

Authors: Efstathios Karathanasis, Rohan Bhavane, Ananth V Annapragada

Published Date October 2007 Volume 2007:2(3) Pages 501 - 513
DOI: http://dx.doi.org/10.2147/IJN.S

Efstathios Karathanasis1, Rohan Bhavane2, Ananth V Annapragada2

1Chemical Engineering Department, University of Houston, Houston, TX, USA; 2School of Health Informatics, University of Texas Health Science Center, Houston, TX, USA

Abstract: In an attempt to achieve post-inhalation self-regulated insulin release, we constructed a microparticle agglomerate of nano-sized liposomal particles, with the agglomeration facilitated by cross-linkages capable of cleavage by glucose. The particles exhibited a small aerodynamic diameter within the human respirable range, but a large geometric diameter that prevents macrophage uptake and clearance. Upon intratracheal instillation of the “glucose-sensitive” microparticle into the lungs of rats, hyperglycemic events triggered an acceleration of the release of insulin achieving normoglycemia shortly after “sensing” the elevated systemic glucose. This work is a demonstration of an inhalable particle with long residence times in the lungs capable of modulating insulin release based on systemic glucose levels.

Keywords: self-regulated release, inhaled insulin, agglomerated vesicle technology, liposomes, glucose sensitive particle








Readers of this article also read:

Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
Tunable drug loading and release from polypeptide multilayer nanofilms
Smart RISUG: A potential new contraceptive and its magnetic field-mediated sperm interaction
Evidence-based decision-making within the context of globalization: A “Why–What–How” for leaders and managers of health care organizations
Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
Amino acid management of Parkinson’s disease: a case study
Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi
Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor
Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation