Back to Browse Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 7

Genetic, host, and environmental interactions in a 19 year old with severe chronic obstructive lung disease; observations regarding the pathophysiology of airflow obstruction

Authors Grosu HB, Killam J, Khusainova E, Lozada J,Needelman A, Eden E

Published Date June 2012 Volume 2012:7 Pages 383—388

DOI http://dx.doi.org/10.2147/COPD.S30325

Received 29 January 2012, Accepted 7 March 2012, Published 22 June 2012

Horiana B Grosu,1 Jonathan Killam,2 Elvina Khusainova,3 James Lozada,1 Andrew Needelman,4 Edward Eden1

1Division of Pulmonary Critical Care and Sleep Medicine, 2Department of Radiology, 3Department of Medicine, St Luke's Roosevelt Hospital Center, New York, 4Mid Hudson Medical Group, Poughkeepsie, New York, USA

Abstract: A case of a 19-year-old with severe chronic obstructive pulmonary disease is presented. This case illustrates genetic (severe alpha-1 antitrypsin deficiency) and host factors (such as developmental diaphragmatic hernia and the innate response to injury), and environmental (high oxidative stress and lung injury) interactions that lead to severe chronic obstructive lung disease. The development of chronic lung disease was caused by lung injury under high oxidative and inflammatory conditions in the setting of a diaphragmatic hernia. In the absence of normal alpha-1 antitrypsin levels, a pro-elastolytic environment in the early period of lung growth enhanced the development of severe hyperinflation and precocious airflow obstruction.

Keywords: Swyer James Macleod syndrome, alpha-1 antitrypsin deficiency, bronchopulmonary dysplasia, chronic obstructive pulmonary disease

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Mécano-Stimulation™ of the skin improves sagging score and induces beneficial functional modification of the fibroblasts: clinical, biological, and histological evaluations

Humbert P, Fanian F, Lihoreau T, Jeudy A, Elkhyat A, Robin S, Courderot-Masuyer C, Tauzin H, Lafforgue C, Haftek M

Clinical Interventions in Aging 2015, 10:387-403

Published Date: 2 February 2015

Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease

Wang TY, Lo YL, Chou PC, Chung FT, Lin SM, Lin TY, Lin HC, Wang CH, Yu CT, Kuo HP

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:231-237

Published Date: 29 January 2015

Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies

Wang Z, Mu HJ, Zhang XM, Ma PK, Lian SN, Zhang FP, Chu SY, Zhang WW, Wang AP, Wang WY, Sun KX

International Journal of Nanomedicine 2015, 10:633-644

Published Date: 14 January 2015

Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis

Lee HJ, Sanetuntikul J, Choi ES, Lee BR, Kim JH, Kim E, Shanmugam S

International Journal of Nanomedicine 2015, 10:271-282

Published Date: 30 December 2014

Functional assessment of geriatric patients in regard to health-related quality of life (HRQoL)

Muszalik M, Kornatowski T, Zielińska-Więczkowska H, Kędziora-Kornatowska K, Dijkstra A

Clinical Interventions in Aging 2015, 10:61-67

Published Date: 19 December 2014

Does food insufficiency in childhood contribute to dementia in later life?

Momtaz YA, Haron SA, Hamid TA, Ibrahim R, Masud J

Clinical Interventions in Aging 2015, 10:49-53

Published Date: 17 December 2014

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

Ito K, Colley T, Mercado N

International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:641-652

Published Date: 21 September 2012

Corrigendum: Softec HD hydrophilic acrylic intraocular lens: biocompatibility and precision

Espandar L, Sikder S, Moshirfar M

Clinical Ophthalmology 2011, 5:159-160

Published Date: 6 February 2011