Factors affecting therapeutic compliance: A review from the patient’s perspective
Jing Jin1, Grant Edward Sklar1, Vernon Min Sen Oh2, Shu Chuen Li3
1Department of Pharmacy, National University of Singapore, Republic of Singapore; 2Department of Clinical Pharmacology and Therapeutics, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore; 3Discipline of Pharmacy and Experimental Pharmacology, School of Biomedical Sciences, University of Newcastle, Callaghan, Australia
Objective: To explore and evaluate the most common factors causing therapeutic noncompliance.
Methods: A qualitative review was undertaken by a literature search of the Medline database from 1970 to 2005 to identify studies evaluating the factors contributing to therapeutic non-compliance.
Results: A total of 102 articles was retrieved and used in the review from the 2095 articles identified by the literature review process. From the literature review, it would appear that the definition of therapeutic compliance is adequately resolved. The preliminary evaluation revealed a number of factors that contributed to therapeutic non-compliance. These factors could be categorized to patient-centered factors, therapy-related factors, social and economic factors, healthcare system factors, and disease factors. For some of these factors, the impact on compliance was not unequivocal, but for other factors, the impact was inconsistent and contradictory.
Conclusion: There are numerous studies on therapeutic noncompliance over the years. The factors related to compliance may be better categorized as “soft” and “hard” factors as the approach in countering their effects may differ. The review also highlights that the interaction of the various factors has not been studied systematically. Future studies need to address this interaction issue, as this may be crucial to reducing the level of non-compliance in general, and to enhancing the possibility of achieving the desired healthcare outcomes.
Keywords: patient compliance, adherence, factors
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Readers of this article also read:
Quantum dots immunofluorescence histochemical detection of EGFR gene mutations in the non-small cell lung cancers using mutation-specific antibodies
Qu YG, Zhang Q, Pan Q, Zhao XD, Huang YH, Chen FC, Chen HL
Published Date: 9 December 2014
A cross-sectional study on perception of stigma by Chinese schizophrenia patients [Expression of concern]
Ren ZB, Wang HQ, Feng B, Gu CY, Ma YC, Chen H, Li BL, Liu LY
Published Date: 18 July 2014
Cetinkaya A, Erden A, Avci D, Karagoz H, Karahan S, Basak M, Bulut K, Gencer V, Mutlu H
Published Date: 27 February 2014
Soosay Raj TA, Smith AM, Moore AS
Published Date: 5 December 2013
Radiofrequency-targeted vertebral augmentation versus traditional balloon kyphoplasty: radiographic and morphologic outcomes of an ex vivo biomechanical pilot study [Erratum]
Published Date: 5 June 2013
Bimatoprost ophthalmic solution 0.03% lowered intraocular pressure of normal-tension glaucoma with minimal adverse events. [Corrigendum]
Tsumura T, Yoshikawa K, Suzumura H, Kimura T, Sasaki S, Kimura I, Takeda R
Published Date: 16 January 2013
Brief G, Lammich T, Nagel E, Pfennigsdorf S, Spraul CW, Ho S
Published Date: 6 August 2012
Published Date: 1 August 2012
Published Date: 27 July 2012
Eduardo Pimenta, Suzanne Oparil
Published Date: 19 May 2009