Extended use of nicotine replacement therapy to maintain smoking cessation in persons with schizophrenia

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Authors: W Dale Horst, Michael W Klein, Denise Williams, Steven F Werder

Published Date February 2005 Volume 2005:1(4) Pages 349 - 355

DOI: http://dx.doi.org/10.2147/NDT.S

W Dale Horst, Michael W Klein, Denise Williams, Steven F Werder

Via Christi Research Inc, Wichita, KS, USA

Abstract: This study was designed to determine the feasibility and efficacy of long-term nicotine replacement therapy (NRT) in helping persons with schizophrenia remain tobaccofree. Fifty smokers with a diagnosis of schizophrenia or schizo-affective disorder and whose symptoms had been stable for at least two months were enrolled in a program providing group support and NRT (patches) in individually adjusted doses set to maintain baseline nicotine intake. All participants attended weekly group support/motivation sessions. Smoking activity was determined by measuring carbon monoxide levels in expired air. Participants who quit tobacco use completely during the first three months were entered into a single-blind phase in which they received either placebo or active nicotine patches for up to six additional months, along with biweekly group sessions. Sixty days into the open-label phase, 66% of the subjects had reduced their use of tobacco by at least 75%. After 90 days of open-label treatment, 18 subjects (36%) were tobacco-free and qualified to enter the six-month, single-blind phase, eight on placebo and nine on active patches. A significantly greater proportion of those on placebo (8 of 8) compared with those on active patches (3 of 9) relapsed prior to completion of the 6-month period. This difference is statistically significant at the p = 0.009 level. The results of this study indicate that long-term use of NRT is feasible and effective for sustained tobacco-free success and may be an important strategy for reducing health risks due to tobacco use in this special population.

Keywords: schizophrenia, smoking cessation, nicotine replacement