skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Extended-release morphine sulfate in treatment of severe acute and chronic pain

Review

(2908) Views  (926) Full article downloads

Authors: Robert J Balch, Andrea Trescot

Published Date September 2010 Volume 2010:3 Pages 191 - 200
DOI: http://dx.doi.org/10.2147/JPR.S6529

Robert J Balch, Andrea Trescot
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA USA

Abstract: Morphine is the archetypal opioid analgesic. Because it is a short-acting opioid, its use has been limited to the management of acute pain. The development of extended-release formulations have resulted in the increased utilization of morphine in chronic pain conditions. This review documents the history of morphine use in pain treatment, and describes the metabolism, pharmacodynamics, formulations, and efficacy of the currently available extended-release morphine medications.

Keywords: Morphine ER, sustained-release morphine, MSContin, Oramorph®, Kadian®, Avinza®, Embeda®






Readers of this article also read:

Yellow flag scores in a compensable New Zealand cohort suffering acute low back pain
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Tapentadol immediate release: a new treatment option for acute pain management
Acute pain management in children
Investigational pharmacology for low back pain
Opioid chronopharmacology: influence of timing of infusion on fentanyl’s analgesic efficacy in healthy human volunteers
Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch
Topical preparations for pain relief: efficacy and patient adherence
Effectiveness and safety of morphine sulfate extended-release capsules in patients with chronic, moderate-to-severe pain in a primary care setting
Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy