Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Evaluation of carboxymethylcellulose 0.5%/glycerin 0.9% and sodium hyaluronate 0.18% artificial tears in patients with mild to moderate dry eye
(4729) Total Article Views
Authors: Roth HW, Conway T, Hollander DA
Published Date November 2011
Volume 2011:3 Pages 73 - 78
Hans-Walter Roth1, Taryn Conway2, David A Hollander2
1Institut für Wissenschaftliche Kontaktoptik Ulm, Ulm/Donau, Germany; 2Allergan, Inc, Irvine, CA, USA
Background: Artificial tears are commonly used for the symptomatic treatment of dry eye. This study compared the efficacy and safety of two preservative-free formulations of artificial tears, carboxymethylcellulose 0.5%/glycerin 0.9% (CMC/glycerin) and sodium hyaluronate 0.18% (sodium hyaluronate), in patients with mild to moderate dry eye symptoms.
Methods: This multicenter, investigator-masked, randomized, parallel-group, active-controlled, clinical study enrolled patients with mild to moderate dry eye symptoms. At baseline, patients received both treatments (one in each eye) and completed an Acute Preference Questionnaire. Patients were then randomized 1:1 to treatment with one drop of CMC/glycerin or sodium hyaluronate at least three times per day for 2 weeks. Efficacy outcomes included Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), corneal staining, conjunctival staining, conjunctival hyperemia, Dry Eye Symptom and Bothersomeness Survey, Patient Acceptability Questionnaire, and Patient Global Assessment of Change. Safety outcomes included the number and frequency of adverse events.
Results: CMC/glycerin and sodium hyaluronate produced statistically significant improvements in OSDI (P < 0.0001), TBUT (P < 0.0001), corneal staining (P < 0.0001), conjunctival staining (P < 0.0001 at Week 1; P < 0.01 at Week 2), and conjunctival hyperemia (P < 0.0001 at Week 1; P < 0.05 at Week 2) relative to baseline. No statistically significant between-group differences in any evaluated variable, including clinical and patient-reported outcomes, were observed. Following a single-drop instillation, there was a trend in favor of sodium hyaluronate for which each drop produced less blurring (P = 0.055). At Day 14, there were trends in favor of CMC/glycerin for questions about how many hours the eyedrops controlled symptoms (P = 0.057), whether the eyedrops effectively relieved dryness (P = 0.053), and which drop provided a cushion of moisture on eyes (P = 0.052). No treatment-related adverse events were reported.
Conclusion: Both CMC/glycerin and sodium hyaluronate effectively relieved dry eye symptoms. Scores were consistently similar across all measures, and both artificial tears were highly acceptable to patients.
Keywords: artificial tears, dry eye, safety, efficacy, carboxymethylcellulose 0.5%/glycerin 0.9%, sodium hyaluronate 0.18%
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
Call For Submissions
Submit Original Research Article, Review, Case Report, or Rapid Communication in Clinical Optometry
- Insight into 144 patients with ocular vascular events during VEGF antagonist injections
- Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine
- Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives
- Dexmedetomidine sedation in painful posterior segment surgery