Evaluation of carboxymethylcellulose 0.5%/glycerin 0.9% and sodium hyaluronate 0.18% artificial tears in patients with mild to moderate dry eye
Hans-Walter Roth1, Taryn Conway2, David A Hollander2
1Institut für Wissenschaftliche Kontaktoptik Ulm, Ulm/Donau, Germany; 2Allergan, Inc, Irvine, CA, USA
Background: Artificial tears are commonly used for the symptomatic treatment of dry eye. This study compared the efficacy and safety of two preservative-free formulations of artificial tears, carboxymethylcellulose 0.5%/glycerin 0.9% (CMC/glycerin) and sodium hyaluronate 0.18% (sodium hyaluronate), in patients with mild to moderate dry eye symptoms.
Methods: This multicenter, investigator-masked, randomized, parallel-group, active-controlled, clinical study enrolled patients with mild to moderate dry eye symptoms. At baseline, patients received both treatments (one in each eye) and completed an Acute Preference Questionnaire. Patients were then randomized 1:1 to treatment with one drop of CMC/glycerin or sodium hyaluronate at least three times per day for 2 weeks. Efficacy outcomes included Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), corneal staining, conjunctival staining, conjunctival hyperemia, Dry Eye Symptom and Bothersomeness Survey, Patient Acceptability Questionnaire, and Patient Global Assessment of Change. Safety outcomes included the number and frequency of adverse events.
Results: CMC/glycerin and sodium hyaluronate produced statistically significant improvements in OSDI (P < 0.0001), TBUT (P < 0.0001), corneal staining (P < 0.0001), conjunctival staining (P < 0.0001 at Week 1; P < 0.01 at Week 2), and conjunctival hyperemia (P < 0.0001 at Week 1; P < 0.05 at Week 2) relative to baseline. No statistically significant between-group differences in any evaluated variable, including clinical and patient-reported outcomes, were observed. Following a single-drop instillation, there was a trend in favor of sodium hyaluronate for which each drop produced less blurring (P = 0.055). At Day 14, there were trends in favor of CMC/glycerin for questions about how many hours the eyedrops controlled symptoms (P = 0.057), whether the eyedrops effectively relieved dryness (P = 0.053), and which drop provided a cushion of moisture on eyes (P = 0.052). No treatment-related adverse events were reported.
Conclusion: Both CMC/glycerin and sodium hyaluronate effectively relieved dry eye symptoms. Scores were consistently similar across all measures, and both artificial tears were highly acceptable to patients.
Keywords: artificial tears, dry eye, safety, efficacy, carboxymethylcellulose 0.5%/glycerin 0.9%, sodium hyaluronate 0.18%
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Readers of this article also read:
Li Nan, Kenneth Seger, Melanie Crandall, et al
Published Date: 6 May 2010
Burak Turgut, Fatih Cem Gul, Tamer Demir, et al
Published Date: 1 June 2010
Paul A Constable, Joshua A Solomon, Sebastian B Gaigg, et al
Published Date: 27 October 2010
Ilechie AA, Tetteh S
Published Date: 18 April 2011
Published Date: 27 July 2011
Evaluation of olopatadine 0.2% in the complete prevention of ocular itching in the conjunctival allergen challenge model
Kabat AG, Granet DB, Amin D, Tort MJ, Blaiss MS
Published Date: 29 July 2011
Xu K, Jhanji V
Published Date: 11 November 2011
Clinical evaluation of a new multi-purpose disinfecting solution in symptomatic wearers of silicone hydrogel contact lenses
Corbin GS, Kading DL, Powell SM, Rosenblatt BD, Secor GB, Maissa CA, Garofalo RJ
Published Date: 26 July 2012
Improving patient outcomes: role of the primary care optometrist in the early diagnosis and management of age-related macular degeneration
Liu L, Swanson M
Published Date: 19 February 2013
Published Date: 1 May 2013