Back to Browse Journals » Breast Cancer: Targets and Therapy » Volume 3

Emerging role of brain metastases in the prognosis of breast cancer patients

Authors

Hambrecht A, Jandial R, Neman J

Published Date August 2011 Volume 2011:3 Pages 79—91

DOI http://dx.doi.org/10.2147/BCTT.S19967

Published 10 August 2011

Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman2
1Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USA

Abstract: Cancer starts with one rogue cell. Through mutations and genomic alterations, the cell acquires specific and stem cell-like characteristics necessary for invasion of a distant organ and ultimately metastasis. Metastatic brain cancer is a particularly formidable disease because of its poor prognosis and the highly resistant nature of the tumor to chemotherapy. Although several types of primary tumors have a tendency to metastasize to the brain, the incidence of brain metastases has increased dramatically in some subsets of breast cancer patients. Several conventional treatments are available, but success is limited and often short-lived. Given that no standard treatment options exist, there is a significant need to investigate the biology of these clinically recalcitrant tumors.

Keywords: metastasis, breast cancer, blood-brain barrier, epithelial-mesenchymal transition, mesenchymal-epithelial transition

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Decreasing glioma recurrence through adjuvant cancer stem cell inhibition

Josh Neman, Rahul Jandial

Biologics: Targets and Therapy 2010, 4:157-162

Published Date: 22 June 2010

Readers of this article also read: