Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study

Original Research

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Authors: Shusaku Ishikawa, Yoshimi Nakamura, Yuko Nakamura, Hiroshi Sakai, Shoichi Sawaguchi, et al

Published Date September 2008 Volume 2008:2(4) Pages 703 - 708

DOI: http://dx.doi.org/10.2147/OPTH.S3997

Shusaku Ishikawa¹, Yoshimi Nakamura¹, Yuko Nakamura¹, Hiroshi Sakai¹, Shoichi Sawaguchi¹, Kazuo Terashima², Makoto Kanno², Hidetoshi Yamashita²

¹Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan; ²Department of Ophthalmology and Visual Science, Yamagata University Faculty of Medicine, Yamagata, Japan

Purpose: To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost.

Methods: A 12-week, prospective, open-label, comparative study was performed in 20 patients [11 males and 9 females, mean age of 64.5 ± 11.0 (SD)y] with POAG or OH treated with both latanoprost once daily and timolol 0.5% twice daily. During the study brinzolamide was substituted for timolol. Intraocular pressure (IOP) was measured at baseline, 4, 8, and 12 weeks. Blood pressure (BP), pulse rate (PR), and adverse events were also recorded.

Results: IOPs at baseline, 4, 8, and 12 weeks were 18.6 ± 2.1 mmHg, 17.8 ± 2.6 mmHg, 17.4 ± 2.5 mmHg, and 17.3 ± 3.5 mmHg, respectively. IOP reduction at 4 and 8 weeks was statistically significant (p < 0.05). The PR was significantly increased at 12 weeks (p < 0.01), but BP was not significantly affected. Four ocular adverse events were noted, but all were mild and transient.

Conclusions: Substituting brinzolamide 1% for timolol 0.5% in combination therapy with latanoprost 0.005% demonstrated significant IOP reduction with improvement in PR with POAG or OH. Combination therapy using latanoprost and brinzolamide may be recommended for better IOP control with fewer systemic adverse events.

Keywords: open-angle glaucoma, brinzolamide/latanprost combination therapy, timolol/latanoprost combination therapy, intraocular pressure