skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Other

(1722) Views  (690) Full article downloads

Authors: Tomohiro Chiba, Marina Yamada, Kosuke Torii, et al

Published Date August 2010 Volume 2010:3 Pages 97 - 104
DOI: http://dx.doi.org/10.2147/JRLCR.S11118

Tomohiro Chiba1, Marina Yamada1, Kosuke Torii2, Masataka Suzuki1, Jumpei Sasabe1, Minoru Ito2, Kenzo Terashita1, Sadakazu Aiso1

1Department of Anatomy, Keio University, School of Medicine, Tokyo, Japan; 2Department of Research and Development, Noevir Co. Ltd., Tokyo, Japan

Abstract: Cholinergic dysfunction is implicated in the pathogenesis of memory impairment related to Alzheimer’s disease (AD). Accordingly, regulation of M1 muscarinic acetylcholine receptor (M1 mAChR) has been one of the major targets in the development of novel drugs for AD. Utilizing an in vitro system for evaluation of the M1 mAChR, we have recently identified that extracts from Cordyceps sinensis (CS) promote M1 mAChR function. In this study, we examined the effect of pretreatment with several types of CS extracts in F11 neurohybrid cells on ERK phosphorylation induced by a muscarinic agonist, carbachol (CCh). A mixed extract of a hot water extract and an ethanol extract from CS augmented ERK phosphorylation by CCh presumably through upregulation of M1 mAChR function. We further examined the effect of oral administration of CS extracts on memory impairment induced by a muscarinic antagonist scopolamine in mice, finding that CS extracts ameliorated scopolamine-induced amnesia in vivo, consistent with the in vitro data. Thus CS extracts may contribute to the prevention of memory impairment related to AD.

Keywords: Cordyceps sinensis, Alzheimer’s disease, m1-muscarinic acetylcholine receptor, memory impairment








Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Pharmacological characterization of oxime agonists of the histamine H4 receptor
Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease
Ligand competition assays indicate allosterism and insufficiency of the ternary complex model
Modularity in receptor evolution: insulin- and glucagon-like peptide modules as binding sites for insulin and glucose in the insulin receptor
Hydrophobicity profiles in G protein-coupled receptor transmembrane helical domains
Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise?
Steroid response pattern and outcome of pediatric idiopathic nephrotic syndrome: a single-center experience in northwest Iran
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy