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8852

Effects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary disease

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Authors: Ferit Akgül, Talantbek Batyraliev, Zarema Karben, Igor Pershukov

Published Date May 2007 Volume 2007:2(1) Pages 77 - 80
DOI: http://dx.doi.org/10.2147/COPD.S

Ferit Akgül1, Talantbek Batyraliev2, Zarema Karben2, Igor Pershukov3

1Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey; 2Sani Konukoglu Medical Center, Cardiology Department, Gaziantep/Turkey; 3Regional Hospital, Voronejh, Russia

Abstract: The purpose of this investigation was to assess the effects of acute hypoxia on left (LV) and right ventricular (RV) contractility in clinically stable chronic obstructive pulmonary disease (COPD) patients. Eleven male patients (mean age 52.4 ± 12.6 years) who were diagnosed to have COPD were included into the study. All of the patients underwent left and right heart catheterization. RV contractility was measured according to the method of Ferlinz and LV contractility according to the method of Kennedy and colleagues using indirect digital substraction angiography. Mean pulmonary artery pressures (Mean PPA) and oxygen saturation of the pulmonary artery (SaO2) were measured before and at each stage of graded hypoxic exposure 14%, 12%, and 10% of O2. Right atrial pressures (PRA,syst, PRA,diast, PRA,mean), RV pressures (PRV,syst, PRV,diast, PRV,mean, PRV,end-diast), RV and LV end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and heart rate (HR) were calculated before and after breathing a hypoxic mixture of 10% of O2 for 30 minutes. Acute hypoxia induced significant elevation of mean PPA, PRA,syst, PRA,diast, PRA,mean, PRV,syst, PRV,mean, PRV,end-diast, RV EDVI, RV ESVI, LV EDVI, LV ESVI, confidence interval, and HR (p < 0.05). Whereas SaO2 decreased significantly after acute hypoxia (p < 0.05). These findings suggest that the systolic performance of the right and left ventricles were well-maintained during acute hypoxia in patients with COPD.

Keywords: acute hypoxia, obstructive pulmonary disease, ventricular contractility.








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