skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals

Original Research

(2727) Views  (579) Full article downloads

Authors: Steven G Denniss, Thomas D Haffner, Jeffrey T Kroetsch, Sara R Davidson, James WE Rush, Richard L Hughson

Published Date March 2008 Volume 2008:4(1) Pages 213 - 222
DOI: http://dx.doi.org/10.2147/VHRM.S2347

Steven G Denniss, Thomas D Haffner, Jeffrey T Kroetsch, Sara R Davidson, James WE Rush, Richard L Hughson

Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada N2L 3G1

Abstract: The objective of this study was to test the hypothesis that the effect of a high-fat meal (HFm) on plasma lipid-soluble antioxidants and biomarkers of vascular oxidative stress and inflammation would be attenuated by short-term lycopene supplementation in young healthy subjects. Following restriction of lycopene-containing foods for 1-wk (LYr), blood was collected in a fasting state and 3 h after a HFm and a low-fat meal (LFm) in N = 18 men aged 23 ± 2 years, and after a HFm only in N = 9 women aged 23 ± 1 years. Blood was also sampled pre- and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr. In the fasting state, LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma β-carotene and α-tocopherol (p<0.01), though LYs did not affect plasma nitrate/nitrite (biomarker of nitric oxide), malondialdehyde (biomarker of lipid oxidative stress), vascular- and intercellular-adhesion molecules or C-reactive protein (biomarkers of inflammation). Contrary to the hypothesis, the HFm-induced dyslipidemic state did not affect plasma malondialdehyde, C-reactive protein, or adhesion molecules in either LYr or LYs. Both the HFm and LFm were associated with decreases in the nitric oxide metabolites nitrate/nitrite and lipid-soluble antioxidants (p<0.05). The data revealed that 1-wk of LYs increased plasma lycopene, β-carotene, and α-tocopherol yet despite these marked changes to the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation were unaffected in the fasted state as well as during dyslipidemia induced by a HFm in young healthy subjects.

Keywords: carotenoids, dietary antioxidants, high-fat meal, low-fat meal








Readers of this article also read:

A hazardous finding of a rare anomalous left main coronary artery in a patient with a secundum atrial septal defect
Kaposiform hemangioendothelioma with distant lymphangiomatosis without an association to Kasabach-Merritt-Syndrome in a female adult!
Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians
Perioperative use of statins in noncardiac surgery
High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease
Prevalence of risk factors, coronary and systemic atherosclerosis in abdominal aortic aneurysm: Comparison with high cardiovascular risk population
Gamma knife radiosurgery for uveal melanoma ineligible for brachytherapy by the Collaborative Ocular Melanoma Study criteria
Refinement of rigid-body protein–protein docking using backbone and side-chain minimization with a coarse-grained model
ABO and rhesus blood group distribution in Kurds
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection?
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University