Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Original Research

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Authors: Inmaculada Tasset, José Peña, Ignacio Jimena, Montserrat Feijóo, María del Carmen Muñoz, et al

Published Date April 2008 Volume 2008:4(2) Pages 441 - 449

DOI: http://dx.doi.org/10.2147/NDT.S2424

Inmaculada Tasset¹, José Peña², Ignacio Jimena², Montserrat Feijóo¹, María del Carmen Muñoz¹, Pedro Montilla¹, Isaac Túnez¹

¹Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain; ²Departamento de Ciencias Morfológicas, Sección de Histología, Facultad de Medicina, Universidad de Córdoba, Spain

Abstract: The present study evaluated 17β-estradiol (17βE₂) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE₂ (14 days). Our results reveled that 17βE₂ has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.

Keywords: behavioral, depression, 17β-estradiol, oxidative stress

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