Decreasing glioma recurrence through adjuvant cancer stem cell inhibition

Review

(2178) Views  (651) Full article downloads

Authors: Josh Neman, Rahul Jandial

Published Date June 2010 Volume 2010:4 Pages 157 - 162

DOI: http://dx.doi.org/10.2147/BTT.S9497

Josh Neman, Rahul Jandial

Division of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USA

Abstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.

Keywords: glioma, cancer stem cells, epigenetic

Other articles by Dr Josh Neman